Histopathological Characteristics of Folliculo-stellate Cells in Pituitary Glands of Wild Type, Obese and High-fat Diet Induced Mice

The anterior pituitary gland regulates growth, metabolism, and reproductionby secreting hormones. Folliculo-stellate cells (FSC) are non-endocrinecells located among hormone-producing in the pituitaryglands, but little is known about exact roles of those cells. Although,with their net organization, they seem to have an important role thehormonal regulation maintenance. In this work, first ever made area, 33 pituitaries three groupsof mice (18 wild type [WT], 11 genetically obese [OB] 4 under a highfat diet [HFD]) were studied order determine if there was any relationbetween number FSC alterations basal metabolism eachgroup mice. For that, immunohistochemical staining using S-100protein used also Image-J software, calculate percentageof present each sample. authors found although wasn’t significant differencebetween WT OB mice, group HFD tend havesubstantially higher percentage than from other groups.This might suggest some yet unknown link between diet, precisely with ahigh-fat presentation pituitary.